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	Rapid and label-free metamaterial-based biosensor for fatty acid detection with terahertz time-domain spectroscopy
	Tang, Mingjie1,2; Xia, Liangping1,3; Wei, Dongshan1,4; Yan, Shihan1; Zhang, Mingkun1; Yang, Zhongbo1; Wang, Huabin1; Du, Chunlei1; Cui, Hong-Liang1
	2020-03-05
摘要	A rapid method for detecting fatty acids (FAs) using terahertz time-domain spectroscopy (THz-TDS) technology combined with a metamaterial-based THz sensor was developed. We measured the THz responses to oleic acid, linoleic acid and alpha-linoleic acid with different numbers of double-bond, alpha-linoleic acid and gamma-linoleic acid with different conformations. In addition, in order to explore the reason for the observed redshifts of the resonance frequencies of the four FAs, the dielectric constants of the FAs were measured in the THz region. Furthermore, the four fatty acids were also attempted to be identified by Raman spectroscopy, which was difficult to accomplish unambiguously because of the effect of fluorescence. This result thus demonstrates the power and usefulness of metamaterial-assisted THz-TDS in the rapid determination of the FAs, and its potential as a versatile tool for investigation of biological metabolism, and for food product quality, safety inspection and control. (C) 2019 Published by Elsevier B.V.
关键词	Fatty acid Terahertz time-domain spectroscopy Label-free THz sensor Dielectric constant
DOI	10.1016/j.saa.2019.117736
发表期刊	SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
ISSN	1386-1425
卷号	228页码:5
通讯作者	Du, Chunlei() ; Cui, Hong-Liang(hcui@cigit.ac.cn)
收录类别	SCI
WOS记录号	WOS:000513010500056
语种	英语