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Gastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the HIF-1 alpha/VEGF signalling pathway
Wang, Rui1,2; Zhang, Ziyue1; Xu, Zaicheng1; Wang, Na1; Yang, Dezhong1; Liu, Zhi Zhao3; Liao, Qiao1; Xia, Xuewei1; Chen, Caiyu1; Shou, Jialing1
2021-08-04
摘要Acute myocardial infarction (MI) is one of the leading causes of death in humans. Our previous studies showed that gastrin alleviated acute myocardial ischaemia-reperfusion injury. We hypothesize that gastrin might protect against heart injury after MI by promoting angiogenesis. An MI model was simulated by ligating the anterior descending coronary artery in adult male C57BL/6J mice. Gastrin was administered twice daily by intraperitoneal injection for 2 weeks after MI. We found that gastrin reduced mortality, improved myocardial function with reduced infarct size and promoted angiogenesis. Gastrin increased HIF-1 alpha and VEGF expression. Downregulation of HIF-1 alpha expression by siRNA reduced the proliferation, migration and tube formation of human umbilical vein endothelial cells. These results indicate that gastrin restores cardiac function after MI by promoting angiogenesis via the HIF-1 alpha /VEGF pathway.
DOI10.1038/s41598-021-95110-7
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号11期号:1页码:10
通讯作者Xia, Tianyang(Xia_ty@126.com) ; Wang, Hongyong(whysir@aliyun.com)
收录类别SCI
WOS记录号WOS:000684831900009
语种英语