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Dewatering fermentation broth for keto carboxylic acid enrichment by forward osmosis: A techno-economic analysis
Szczygielda, Mateusz1; Krajewska, Martyna1; Andrzejewski, Adam1; Zheng, Lei2; Nghiem, Long D.3; Oleskowicz-Popiel, Piotr4; Szymanowska, Daria5; Prochaska, Krystyna1
2023-08-05
摘要This study demonstrated the importance of fermentation broth pretreatment and dewatering by forward osmosis (FO) before keto carboxylic acid recovery. The most effective and profitable pretreatment procedure was a combination of centrifugation, ceramic ultrafiltration of molecular weight cut-off of 15 kDa, and ceramic nanofiltration of molecular weight cut-off of 450 Da. By applying the complex pretreatment and FO as a preconcentration step of fermentation broth dewatering, the keto acid enrichment of two times was achieved for alpha-ketoglutaric acid and pyruvic acid. Extensive fouling analysis performed in this study confirmed that the proposed pretreatment procedure was sufficient to avoid severe fouling of the FO dewatering process. A technoeconomic analysis of the proposed keto acid extraction scheme shown that by using FO for fermentation broth dewatering, the total capital investment was reduced and the payback time was shortened by 0.83 yr.
关键词Forward osmosis Pretreatment Fouling analysis Techno-economic analysis
DOI10.1016/j.memsci.2023.121699
发表期刊JOURNAL OF MEMBRANE SCIENCE
ISSN0376-7388
卷号679页码:9
通讯作者Szczygielda, Mateusz(mateusz.szczygielda@put.poznan.pl)
收录类别SCI
WOS记录号WOS:000999500900001
语种英语