中国科学院重庆绿色智能技术研究院机构知识库

QQ客服 官方微博 反馈留言

	Disease types and pathogenic mechanisms induced by PM2.5 in five human systems: An analysis using omics and human disease databases
	Zhang, Shumin1; Li, Xiaomeng1,2,3; Zhang, Liru1; Zhang, Zhengliang1,4; Li, Xuan1,4; Xing, Yan3; Wenger, John C.5,6; Long, Xin2; Bao, Zhier2; Qi, Xin2
	2024-08-01
摘要	Atmospheric fine particulate matter (PM 2.5 ) can harm various systems in the human body. Due to limitations in the current understanding of epidemiology and toxicology, the disease types and pathogenic mechanisms induced by PM 2.5 in various human systems remain unclear. In this study, the disease types induced by PM 2.5 in the respiratory, circulatory, endocrine, and female and male urogenital systems have been investigated and the pathogenic mechanisms identified at molecular level. The results reveal that PM 2.5 is highly likely to induce pulmonary emphysema, reperfusion injury, malignant thyroid neoplasm, ovarian endometriosis, and nephritis in each of the above systems respectively. The most important co -existing gene, cellular component, biological process, molecular function, and pathway in the five systems targeted by PM 2.5 are Fos proto-oncogene (FOS), extracellular matrix, urogenital system development, extracellular matrix structural constituent conferring tensile strength, and ferroptosis respectively. Differentially expressed genes that are significantly and uniquely targeted by PM 2.5 in each system are BTG2 (respiratory), BIRC5 (circulatory), NFE2L2 (endocrine), TBK1 (female urogenital) and STAT1 (male urogenital). Important disease -related cellular components, biological processes, and molecular functions are specifically induced by PM 2.5 . For example, response to wounding, blood vessel morphogenesis, body morphogenesis, negative regulation of response to endoplasmic reticulum stress, and response to type I interferon are the top uniquely existing biological processes in each system respectively. PM 2.5 mainly acts on key disease -related pathways such as the PD -L1 expression and PD -1 checkpoint pathway in cancer (respiratory), cell cycle (circulatory), apoptosis (endocrine), antigen processing and presentation (female urogenital), and neuroactive ligand-receptor interaction (male urogenital). This study provides a novel analysis strategy for elucidating PM 2.5 -related disease types and is an important supplement to epidemiological investigation. It clarifies the risks of PM 2.5 exposure, elucidates the pathogenic mechanisms, and provides scientific support for promoting the precise prevention and treatment of PM 2.5 -related diseases.
关键词	PM2.5 Pathogenic mechanisms Respiratory system Circulatory system Endocrine system Urogenital systems
DOI	10.1016/j.envint.2024.108863
发表期刊	ENVIRONMENT INTERNATIONAL
ISSN	0160-4120
卷号	190页码:14
通讯作者	Chen, Yang(chenyang@cigit.ac.cn)
收录类别	SCI
WOS记录号	WOS:001264338700001
语种	英语