KMS Chongqing Institute of Green and Intelligent Technology, CAS
Direct oxidative cyanation of tertiary amines promoted by in situ generated hypervalent iodine(III)-CN intermediate | |
Shen, Hang1; Zhang, Xiaohui1; Liu, Qing1; Pan, Jing1; Hu, Wen1; Xiong, Yan1,2; Zhu, Xiangming3 | |
2015-10-07 | |
摘要 | An environmentally benign and metal-free cyanation method of tertiary amines oxidated by hypervalent iodine(III) intermediate generated in situ from PIFA (or DIB) and TMSCN has been developed. A variety of substituent groups on amines are tolerated to the oxidation of alpha-C-H bond to form C-C bond in the absence of metal catalysts with yields of up to 74%. (C) 2015 Elsevier Ltd. All rights reserved. |
关键词 | Alpha-aminonitriles Cyanation n,N-dialkylanilines Hypervalent Iodine Tmscn |
DOI | 10.1016/j.tetlet.2015.08.058 |
发表期刊 | TETRAHEDRON LETTERS |
ISSN | 0040-4039 |
卷号 | 56期号:41页码:5628-5631 |
收录类别 | SCI |
WOS记录号 | WOS:000361926100034 |
语种 | 英语 |